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pentobarbital will reduce the level or influence of nilotinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.pentobarbital will increase effects of ifosfamide by affecting hepatic enzyme CYP2B6 metabolism. Use Warning/Watch. Coadministration of ifosfamide with CYP2B6 inducers may perhaps boost metabolism of ifosfamide